Germline Epigenetic Inheritance

Background

I have studied and written extensively about germline epigenetic inheritance (GEI), especially the possibility that paternal exposures before conception could influence offspring biology through sperm epigenetic mechanisms. This work is most directly represented in my review with Chris Kuzawa, which considered the promise, limitations, and ethical implications of studying GEI in humans.

GEI remains an important conceptual area for me, but it is no longer a central focus of my active research program. I keep it here because it continues to shape how I think about development, inheritance, intergenerational effects, and the challenges of translating findings from model organisms into human population research.

Current Relevance

My current work connects to these questions most directly through studies of maternal physiology, placental development, and assisted reproduction. For example, projects comparing IVF surrogate and genetically related pregnancies provide opportunities to separate aspects of maternal experience, genetics, and placental biology in ways that are relevant to broader questions about intergenerational transmission.

I remain interested in future work on paternal exposures, sperm epigenetics, and offspring health, particularly when these questions can be addressed with strong study designs, rich longitudinal data, and careful attention to social context. For now, GEI is best understood as a continuing theoretical interest and area of expertise rather than the main direction of my research program.